Rexulti (brexpiprazole) may not be safe to take while pregnant or breastfeeding. Certain factors, including the risks of not treating your condition during pregnancy and fetal harm, may determine whether you should take the drug during this time.

Rexulti doesn’t have specific information about the risk of taking it during pregnancy. But some research shows that taking similar drugs during the third trimester of pregnancy increases the risk of extrapyramidal symptoms in infants exposed to the drugs. (Extrapyramidal symptoms are movement disorders related to drugs.)

Further, taking Rexulti during the third trimester of pregnancy may increase the risk of withdrawal symptoms in infants exposed to the drug. Withdrawal symptoms can include:

  • difficulty breathing or feeding
  • sleepiness
  • tremor
  • agitation

Discuss the risks and benefits of taking Rexulti during pregnancy with your doctor. If you become pregnant during Rexulti treatment, tell your doctor right away.

Treating the condition

Rexulti has approval from the Food and Drug Administration (FDA) to treat the following conditions:

It’s important to note that not treating your diagnosed condition during pregnancy may carry certain risks. Because of this, you and your doctor should discuss the risks and benefits of taking Rexulti while pregnant versus not treating your condition during pregnancy.

Pregnancy registry

If you take Rexulti during pregnancy, consider signing up for the pregnancy registry. It evaluates the safety of medications called atypical antipsychotics, which include Rexulti. To learn more, visit the registry website or call 866-961-2388.

If you’re currently breastfeeding or planning to do so, it’s important to understand the effects that Rexulti could have on you or the breastfed child.

It isn’t known whether Rexulti is safe to take while breastfeeding. The drug could pass into breast milk, which may cause side effects in a breastfed child.

Your doctor can discuss the risk of taking Rexulti if you plan to breastfeed. If you are breastfeeding, they can recommend whether you should stop during treatment with this drug.

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