Set up in a clean, private space with access to soap and water for handwashing. It’s also helpful to have a liner or menstrual pad in place in your underwear to manage any discharge after insertion.

A vaginal suppository is a solid, medicated product designed to dissolve inside the vaginal canal. They’re typically cone- or oval-shaped to help facilitate insertion.

Unless directed otherwise by a healthcare professional, it’s best to insert the suppository at bedtime. Lying down afterward helps prevent leakage and allows the medication to be absorbed more effectively.

Check the instructions to see if an applicator is included and whether it’s reusable or single-use.

If the suppositories are individually wrapped, you can lightly press the packaging to check its firmness. You may need to run the package under cold water or place it in the fridge to firm up the medication for easier insertion.

When you’re ready to start, wash your hands with soap and warm water. This prevents the introduction of bacteria into the vaginal canal.

Dry your hands thoroughly, then unwrap or remove the suppository from its packaging

You can insert a vaginal suppository while:

  • lying on your back with your knees bent
  • standing with one foot elevated on a toilet seat or chair
  • squatting

Choose the position that gives you the most control and comfort.

If you don’t have an applicator or are using your fingers:

  • Hold the suppository between your thumb and index finger.
  • Gently insert it into the vaginal opening.
  • Push it in about 1 to 2 inches (2.5 to 5 cm), or until it feels secure and comfortable.

If you’re using an applicator:

  • Place the suppository into the tip of the applicator.
  • Gently insert the applicator into the vaginal canal.
  • Depress the plunger to release the suppository.
  • Carefully withdraw the applicator and set it aside for cleaning or disposal.

Lie down for at least 10 to 15 minutes to allow the suppository to begin dissolving. This minimizes leakage and enhances absorption.

Wash your hands again with soap and warm water. Clean reusable applicators according to the manufacturer’s instructions.

Some discharge is expected as the suppository melts. You might find it helpful to use an underwear liner or a light menstrual pad to protect your clothes or linens.

Do:

  • Complete the full course of treatment.
  • Wear loose, breathable clothing to minimize moisture and irritation.
  • Change your underwear, liner, or pad as needed to prevent moisture buildup.

Don’t:

  • Do not use tampons to collect vaginal discharge. Tampons will absorb the medication.
  • Do not use menstrual cups or discs to collect vaginal discharge. Cups and discs may interfere with absorption.
  • Do not have partnered vaginal sex until you complete the full course of treatment.

Always confirm the diagnosis before self-treating with over-the-counter suppositories, especially if your symptoms are new or severe.

You should also consult a healthcare professional before use if you:

After use, consult a doctor or other healthcare professional if you:

  • develop new or worsening symptoms, including unusual bleeding or odor
  • have hives, swelling, or rash, which are symptoms of an allergic reaction
  • still have symptoms after completing the full course of treatment

Vaginal suppositories are used to treat:

 

Vaginal suppositories provide faster symptom relief because they deliver medication directly to the affected area. This reduces the risk of whole-body side effects.

They’re also a good option for people who can’t take oral drugs due to swallowing difficulties, digestive symptoms, or drug interactions.

Vaginal suppositories are generally safe for most people. Some people experience mild itching, burning, or other irritation after insertion, but these side effects are usually temporary.

Suppositories typically begin to dissolve within 10 to 15 minutes after insertion, with full absorption of the medication occurring gradually over several hours.

Yes, you can pee after using a vaginal suppository. Urination is released through the urethra, which is a different opening than the vagina. However, it’s best to go beforehand or wait until after the medication begins to absorb.

Vaginal suppositories offer a safe and effective way to deliver medication directly where it’s needed, whether you’re treating an infection, managing dryness, or using hormone therapy.

Following instructions carefully, maintaining good hygiene, and completing the full course of treatment will help you get the most out of your medication.