There are several ways you can help manage constipation caused by Zepbound. These include increasing your daily fluid intake, eating more fiber-rich foods, and staying physically active.
Because Zepbound slows down the movement of food through your digestive tract, these lifestyle habits are essential to help keep your system regular. If these natural methods do not provide relief, talk with your doctor about using over-the-counter stool softeners or gentle laxatives.
Zepbound belongs to a class of drugs called GLP-1 and GIP receptor agonists. These medications work by mimicking hormones that signal fullness to your brain. One of the main ways they achieve this is by slowing gastric emptying, which means food stays in your stomach and intestines for a longer time.
While this process helps with weight loss, the slower movement allows the colon to absorb more water from the waste, often leading to harder stools and constipation.
Constipation has been reported in clinical trials of Zepbound. The prescribing information lists constipation as a common side effect at several dose levels, but the reported rates do not clearly increase as the dose becomes higher.
Most people find that these symptoms are most prominent during the first few weeks of a dose increase and usually stabilize as the body adjusts to the medication.
To get rid of constipation on GLP-1 medications, focus on consistent hydration. Aim to drink water throughout the day, even if you don’t feel thirsty.
Gradually increase your fiber intake by eating more legumes, vegetables, and whole grains. Adding fiber too quickly can cause gas and bloating, so introduce it slowly.
Additionally, regular movement, such as a brisk 20-minute walk, helps stimulate the muscles in your gut to move waste along.
Talk with a healthcare professional if your symptoms become more frequent or severe.
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